Multiple Sclerosis Relapses Following Cessation of Fingolimod.

ABSTRACT:

Background

There is growing interest in the issue of disease reactivation in multiple sclerosis following fingolimod cessation. Relatively little is known about modifiers of the risk of post-cessation relapse, including the delay to commencement of new therapy and prior disease activity.

Objective

We aimed to determine the rate of relapse following cessation of fingolimod and to identify predictors of relapse following cessation.

Methods

Data were extracted from the MSBase registry in March 2019. Inclusion criteria were (a) clinically definite relapsing multiple sclerosis, (b) treatment with fingolimod for ≥ 12 months, (c) follow-up after cessation for ≥ 12 months, and (d) at least one Expanded Disability Status Scale score recorded in the 12 months before cessation.<

SUBMITTER: Malpas CB 

PROVIDER: S-EPMC8989797 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature