Inhibition of BK_Ca channels protects neonatal hearts against myocardial ischemia and reperfusion injury.

ABSTRACT: BK_Ca channels are large-conductance calcium and voltage-activated potassium channels that are heterogeneously expressed in a wide array of cells. Activation of BK_Ca channels present in mitochondria of adult ventricular cardiomyocytes is implicated in cardioprotection against ischemia-reperfusion (IR) injury. However, the BK_Ca channel's activity has never been detected in the plasma membrane of adult ventricular cardiomyocytes. In this study, we report the presence of the BK_Ca channel in the plasma membrane and mitochondria of neonatal murine and rodent cardiomyocytes, which protects the heart on inhibition but not activation. Furthermore, K⁺ currents measured in neonatal cardiomyocyte (NCM) was sensitive to iberiotoxin (IbTx), suggesti

SUBMITTER: Sanghvi S 

PROVIDER: S-EPMC8989942 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature