An Amish founder population reveals rare-population genetic determinants of the human lipidome.

ABSTRACT: Identifying the genetic determinants of inter-individual variation in lipid species (lipidome) may provide deeper understanding and additional insight into the mechanistic effect of complex lipidomic pathways in CVD risk and progression beyond simple traditional lipids. Previous studies have been largely population based and thus only powered to discover associations with common genetic variants. Founder populations represent a powerful resource to accelerate discovery of previously unknown biology associated with rare population alleles that have risen to higher frequency due to genetic drift. We performed a genome-wide association scan of 355 lipid species in 650 individuals from the Amish founder population including 127 lipid species not previously tested. To the best of our knowledge,

SUBMITTER: Montasser ME 

PROVIDER: S-EPMC8989972 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature