Spontaneous regression rates of actinic keratosis: a systematic review and pooled analysis of randomized controlled trials.

ABSTRACT: Actinic keratosis (AK) are precancerous lesions of the skin which may progress to invasive squamous cell carcinoma. However, single lesions may also persist or even regress and heal spontaneously. Until now, evidence on the natural course of AK including spontaneous regression is limited. We aimed to synthesize regression rates of AK. We performed a systematic literature research in Medline, Embase, and CENTRAL for eligible trials until 3rd March 2020. Spontaneous regression rates were pooled using a random-effects model to calculate pooled proportions of participant-specific and lesion-specific complete clearance rates reported for the placebo arms of randomized controlled trials. Subgroup analyses were performed to dissect differences according to the type of placebo, immunocompetence of

SUBMITTER: Steeb T 

PROVIDER: S-EPMC8990007 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature