The Changes of Amygdala Transcriptome in Autism Rat Model After Arginine Vasopressin Treatment.

ABSTRACT:

Background

Some studies have shown that arginine vasopressin (AVP) can significantly improve the social interaction disorder of autism, but the mechanism remains unclear.

Methods

Female Wistar rats were intraperitoneally injected with VPA or normal saline at embryonic day 12.5 to establish an autism model or normal control in their offspring. Male offspring prenatally exposed to VPA were randomly assigned to two groups: the VPA-induced autism model group and the AVP group. The rats in the AVP group were treated with intranasal AVP at postnatal day (PND) 21 and for 3 weeks. The VPA-induced autism model group was given the same dose of normal saline in the same way. Behavioral responses were evaluated in the open field and three-chambered social test apparatus; the expression

SUBMITTER: Zhou B 

PROVIDER: S-EPMC8990166 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature