Association of pre-ESKD hyponatremia with post-ESKD outcomes among incident ESKD patients.

ABSTRACT:

Background

Hyponatremia is one of the most common electrolyte disturbances in advanced chronic kidney disease (CKD) and end-stage kidney disease (ESKD) patients, and has been shown to be associated with higher mortality risk. However, the relationship between hyponatremia during late-stage CKD and the risk of poor outcomes after ESKD transition is unknown.

Methods

We conducted a retrospective cohort study including 32 257 US veterans transitioning to ESKD from 1 October 2007 to 30 March 2015. We evaluated adjusted associations between the 3-month averaged pre-transition to ESKD serum sodium and all-cause mortality. Secondary outcomes included cardiovascular (CV) mortality, infection-related mortalities and hospitalization rate.

Results

Cohort mean ± standard deviation

SUBMITTER: Marroquin MV 

PROVIDER: S-EPMC8990245 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature