TRAF6 regulates the signaling pathway influencing colorectal cancer function through ubiquitination mechanisms.

ABSTRACT: Tumor necrosis factor receptor-associated factor-6 (TRAF6) is a ubiquitin E3 ligase. TRAF6 plays an important role in tumor invasion and metastasis. However, the specific mechanism by which TRAF6 promotes colorectal cancer (CRC) metastasis is incompletely understood. This study aimed to determine whether TRAF6 affects the LPS-NF-κB-VEGF-C signaling pathway through ubiquitination, which plays a role in colorectal cancer metastasis. Here, our results showed that TRAF6 affected lymphangiogenesis through the LPS-NF-κB-VEGF-C signaling pathway. Using ubiquitination experiments, we found that TRAF6 was mainly ubiquitinated with the K63-linked chains, and LPS promoted ubiquitination of TRAF6 and K63-linked chains. More importantly, TRAF6 124mut is the main ubiquitination site of TRAF6 interacting

SUBMITTER: Guangwei Z 

PROVIDER: S-EPMC8990288 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature