Antigen cross-presentation in young tumor-bearing hosts promotes CD8⁺ T cell terminal differentiation.

ABSTRACT: The immune system undergoes a progressive functional remodeling with age. Understanding how age bias shapes antitumor immunity is essential in designing effective immunotherapies, especially for pediatric patients. Here, we explore antitumor CD8⁺ T cell responses generated in young (prepubescent) and adult (presenescent) mice. Using an MHCI-deficient tumor model, we observed that tumor-reactive CD8⁺ T cells expanded in young tumor-bearing (TB) mice acquired a terminally differentiated phenotype characterized by overexpression of inhibitory receptors and the transcription factor Tox1. Furthermore, tumor-infiltrating CD8⁺ T cells from young tumors yielded a poor cytokine response compared with CD8⁺ T cells infiltrating adult tumors. Young migratory

SUBMITTER: Moustaki A 

PROVIDER: S-EPMC8990347 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature