Effect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Following Extubation on Liberation From Respiratory Support in Critically Ill Children: A Randomized Clinical Trial.

ABSTRACT:

Importance

The optimal first-line mode of noninvasive respiratory support following extubation of critically ill children is not known.

Objective

To evaluate the noninferiority of high-flow nasal cannula (HFNC) therapy as the first-line mode of noninvasive respiratory support following extubation, compared with continuous positive airway pressure (CPAP), on time to liberation from respiratory support.

Design, setting, and participants

This was a pragmatic, multicenter, randomized, noninferiority trial conducted at 22 pediatric intensive care units in the United Kingdom. Six hundred children aged 0 to 15 years clinically assessed to require noninvasive respiratory support within 72 hours of extubation were recruited between August 8, 2019, and May 18, 2020, with last f

SUBMITTER: Ramnarayan P 

PROVIDER: S-EPMC8990361 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature