Dysregulated mitochondrial metabolism upon cigarette smoke exposure in various human bronchial epithelial cell models.

ABSTRACT: Exposure to cigarette smoke (CS) is the primary risk factor for developing chronic obstructive pulmonary disease. The impact of CS exposure on the molecular mechanisms involved in mitochondrial quality control in airway epithelial cells is incompletely understood. Undifferentiated or differentiated primary bronchial epithelial cells were acutely/chronically exposed to whole CS (WCS) or CS extract (CSE) in submerged or air-liquid interface conditions. Abundance of key regulators controlling mitochondrial biogenesis, mitophagy and mitochondrial dynamics was assessed. Acute exposure to WCS or CSE increased the abundance of components of autophagy and receptor-mediated mitophagy in all models. Although mitochondrial content and dynamics appeared to be unaltered in response to CS, changes in bo

SUBMITTER: Tulen CBM 

PROVIDER: S-EPMC8990921 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature