Side-effects of oxytocin in postpartum hemorrhage: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the side-effects of oxytocin for the prevention of postpartum hemorrhage (PPH) in randomized controlled trials (RCTs).

Methods

Electronic databases (Web of Science, Embase, PubMed, Elsevier ScienceDirect, the Cochrane Library, and ClinicalTrials.gov) were searched from the beginning of indexing to Sep 2021. RCTs comparing oxytocin with non-oxytocin uterotonic agent(s) or non-pharmacologic interventions for the prevention of PPH were eligible.

Results

Overall, sixty-one RCTs meeting the inclusion criteria were included, involving 68834 participants. Twenty-seven types of side-effects were reported in this study. There were 24, 35, or 2 trials assessed as high medium and low quality, respectively. Compared with non-oxytocin, oxytocin had significan

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC8991119 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature