Dataset Information

Side-effects of oxytocin in postpartum hemorrhage: a systematic review and meta-analysis.

ABSTRACT:

Objective

To evaluate the side-effects of oxytocin for the prevention of postpartum hemorrhage (PPH) in randomized controlled trials (RCTs).

Methods

Electronic databases (Web of Science, Embase, PubMed, Elsevier ScienceDirect, the Cochrane Library, and ClinicalTrials.gov) were searched from the beginning of indexing to Sep 2021. RCTs comparing oxytocin with non-oxytocin uterotonic agent(s) or non-pharmacologic interventions for the prevention of PPH were eligible.

Results

Overall, sixty-one RCTs meeting the inclusion criteria were included, involving 68834 participants. Twenty-seven types of side-effects were reported in this study. There were 24, 35, or 2 trials assessed as high medium and low quality, respectively. Compared with non-oxytocin, oxytocin had significantly lower risk for shivering (RR=0.31, 95% CI=0.23-0.41, n=36680), fever (RR=0.27, 95% CI=0.20-0.37, n=34031), and diarrhea (RR=0.48, 95% CI=0.35-0.66, n=30883). Other side-effects were not found associated with oxytocin.

Conclusion

Oxytocin use was association with a significantly lower incidence of shivering, fever, and diarrhea events and did not increase risk of other side-effects during the third stage of labor. These observations may aid obstetricians and gynecologists in weighing up the benefits and risks associated with oxytocin in prevention and treatment of PPH during the third stage of labor.

SUBMITTER: Zeng Y

PROVIDER: S-EPMC8991119 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Side-effects of oxytocin in postpartum hemorrhage: a systematic review and meta-analysis.

Zeng Yanfei Y Zhang Yinghui Y Zhen Manhua M Lao Li L Ma Yubo Y Liu Li L Fan Dazhi D Ai Wen W

American journal of translational research 20220315 3

<h4>Objective</h4>To evaluate the side-effects of oxytocin for the prevention of postpartum hemorrhage (PPH) in randomized controlled trials (RCTs).<h4>Methods</h4>Electronic databases (Web of Science, Embase, PubMed, Elsevier ScienceDirect, the Cochrane Library, and ClinicalTrials.gov) were searched from the beginning of indexing to Sep 2021. RCTs comparing oxytocin with non-oxytocin uterotonic agent(s) or non-pharmacologic interventions for the prevention of PPH were eligible.<h4>Results</h4>O ...[more]

PMID: 35422945

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Dataset Information

Side-effects of oxytocin in postpartum hemorrhage: a systematic review and meta-analysis.

Objective

Methods

Results

Conclusion

Publications

Side-effects of oxytocin in postpartum hemorrhage: a systematic review and meta-analysis.

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