SOX18-associated gene signature predicts sepsis outcome.

ABSTRACT:

Objectives

Sepsis is a critical medical condition associated with an high mortality. Currently, there are no reliable diagnostic or prognostic biomarkers to evaluate sepsis outcomes. SRY (sex-determining region on the Y chromosome)-box transcription factor 18 (SOX18) is an endothelial barrier protective protein, and a decreased level of SOX18 expression is involved in disruption of human endothelial cell barrier integrity. Over-expression of SOX18 attenuates the bacterial lipopolysaccharide (LPS)-mediated disruption of the vascular barrier and is associated with favorable prognosis. The utility of SOX18-related genes as biomarkers in sepsis is uncertain.

Methods

Transcriptomic analysis was used to profile the PBMC samples of patients with sepsis across two Gene Expression Om

SUBMITTER: Feng A 

PROVIDER: S-EPMC8991122 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature