Effects of Early Intensive Insulin Therapy on Endothelial Progenitor Cells in Patients with Newly Diagnosed Type 2 Diabetes.

ABSTRACT:

Aim

This study aimed to investigate the alteration of circulating CD34⁺KDR⁺CD133⁺ endothelial progenitor cells (EPCs) in patients with newly diagnosed type 2 diabetes and the mechanism of the effect of early intensive insulin therapy.

Methods

In this study, 36 patients with newly diagnosed type 2 diabetes and 22 control subjects matched by age and gender were enrolled. All of the patients with diabetes received intensive insulin therapy. The number of EPCs was assessed by flow cytometry based on the expression of CD34, CD133, and kinase insert domain-containing receptor (KDR).

Results

Levels of circulating CD34⁺KDR⁺CD133⁺ EPCs were higher in patients with diabetes compared to control subjects and signif

SUBMITTER: Zhang W 

PROVIDER: S-EPMC8991286 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature