Oxidative Stress in Intervertebral Disc Degeneration: New Insights from Bioinformatic Strategies.

ABSTRACT: Oxidative stress has been proved to play important roles in the development of intervertebral disc degeneration (IDD); however, the underlying mechanism remains obscure to date. The aim of this study was to elucidate the vital roles of oxidative stress-related genes in the development of IDD using strict bioinformatic algorithms. The microarray data relevant to the IDD was downloaded from Gene Expression Omnibus database for further analysis. A series of bioinformatic strategies were used to determine the oxidative stress-related and IDD-related genes (OSIDDRGs), perform the function enrichment analysis and protein-protein interaction analysis, construct the lncRNA-miRNA-mRNA regulatory network, and investigate the potential relationship of oxidative stress to immunity abnormality and auto

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC8991415 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature