KCNQ1 and lymphovascular invasion are key features in a prognostic classifier for stage II and III colon cancer.

ABSTRACT:

Background

The risk of recurrence after resection of a stage II or III colon cancer, and therefore qualification for adjuvant chemotherapy (ACT), is traditionally based on clinicopathological parameters. However, the parameters used in clinical practice are not able to accurately identify all patients with or without minimal residual disease. Some patients considered 'low-risk' do develop recurrence (undertreatment), whilst other patients receiving ACT might not have developed recurrence at all (overtreatment). We previously analysed tumour tissue expression of 28 protein biomarkers that might improve identification of patients at risk of recurrence. In the present study we aimed to build a prognostic classifier based on these 28 biomarkers and clinicopathological parameters.

Me

SUBMITTER: Uil SH 

PROVIDER: S-EPMC8991490 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature