Long noncoding RNA MALAT1 polymorphism predicts MACCEs in patients with myocardial infarction.

ABSTRACT:

Background

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) participates in the occurrence and development of cardiovascular and cerebrovascular diseases such as stroke and coronary heart disease by regulating inflammatory reactions, programmed cell death, and other pathological processes. Previous studies revealed that the MALAT1 gene polymorphism was associated with cardiac and cerebrovascular diseases. However, the prognostic role of the MALAT1 polymorphism in major adverse cardiac and cerebrovascular events (MACCEs) remains unknown. Therefore, this study intends to explore the association between the MALAT1 rs3200401 polymorphism and MACCEs.

Method

We enrolled 617 myocardial infarction (MI) patients and 1125 control participants who attended the First Affi

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8991554 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature