Systems Genomics Identifies a Key Role for Hypocretin/Orexin Receptor-2 in Human Heart Failure.

ABSTRACT:

Background

The genetic determinants of heart failure (HF) and response to medical therapy remain unknown. We hypothesized that identifying genetic variants of HF that associate with response to medical therapy would elucidate the genetic basis of cardiac function.

Objectives

This study sought to identify genetic variations associated with response to HF therapy.

Methods

This study compared extremes of response to medical therapy in 866 HF patients using a genome-wide approach that informed the systems-based design of a customized single nucleotide variant array. The effect of genotype on gene expression was measured using allele-specific luciferase reporter assays. Candidate gene transcription-deficient mice underwent echocardiography and treadmill exercise. The abili

SUBMITTER: Perez MV 

PROVIDER: S-EPMC8991813 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature