Comparing methods for handling missing cost and quality of life data in the Early Endovenous Ablation in Venous Ulceration trial.

ABSTRACT:

Objectives

This study compares methods for handling missing data to conduct cost-effectiveness analysis in the context of a clinical study.

Methods

Patients in the Early Endovenous Ablation in Venous Ulceration (EVRA) trial had between 1 year and 5.5 years (median 3 years) of follow-up under early or deferred endovenous ablation. This study compares complete-case-analysis (CCA), multiple imputation using linear regression (MILR) and using predictive mean matching (MIPMM), Bayesian parametric approach using the R package missingHE (BPA), repeated measures fixed effect (RMFE) and repeated measures mixed model (RMM). The outcomes were total mean costs and total mean quality-adjusted life years (QALYs) at different time horizons (1 year, 3 years and 5 years).

Results

All

SUBMITTER: Diop M 

PROVIDER: S-EPMC8991820 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature