Multi-omics data integration analysis identifies the spliceosome as a key regulator of DNA double-strand break repair.

ABSTRACT: DNA repair by homologous recombination (HR) is critical for the maintenance of genome stability. Germline and somatic mutations in HR genes have been associated with an increased risk of developing breast (BC) and ovarian cancers (OvC). However, the extent of factors and pathways that are functionally linked to HR with clinical relevance for BC and OvC remains unclear. To gain a broader understanding of this pathway, we used multi-omics datasets coupled with machine learning to identify genes that are associated with HR and to predict their sub-function. Specifically, we integrated our phylogenetic-based co-evolution approach (CladePP) with 23 distinct genetic and proteomic screens that monitored, directly or indirectly, DNA repair by HR. This omics data integration analysis yielded a new

SUBMITTER: Sherill-Rofe D 

PROVIDER: S-EPMC8991968 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature