Exploration of expanded carbohydrate chemical space to access biological activity using microwave-induced acid condensation of simple sugars.

ABSTRACT: Complex glycans are ubiquitous in nature and essential to life. Despite their diverse roles, however, only a fraction of their potential chemical space has been explored. New regions of this chemical space can, nevertheless, be accessed by generating structures that do not occur in nature or by modifying naturally-occurring polysaccharide structures - collectively, termed new polysaccharides (NPs). Two synthetic routes to NPs are described; the de novo route, directly from monosaccharide starting materials and the functionalization route, involving glycosylation of existing polysaccharides. The reaction involves a simple condensation step under microwave heating, catalysed by environmentally benign organic acids and is illustrated by the generation of structures with biological acti

SUBMITTER: London JA 

PROVIDER: S-EPMC8992359 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature