Therapeutic modulation of the CD47-SIRPα axis in the pediatric tumor microenvironment: working up an appetite.

ABSTRACT: Evasion of immune surveillance is one of the hallmarks of cancer. Although the adaptive immune system has been targeted via checkpoint inhibition, many patients do not sustain durable remissions due to the heterogeneity of the tumor microenvironment, so additional strategies are needed. The innate immune system has its own set of checkpoints, and tumors have co-opted this system by expressing surface receptors that inhibit phagocytosis. One of these receptors, CD47, also known as the "don't eat me" signal, has been found to be overexpressed by most cancer histologies and has been successfully targeted by antibodies blocking the receptor or its ligand, signal regulatory protein α (SIRPα). By enabling phagocytosis via antigen-presenting cells, interruption of CD47-SIRPα binding leads to earl

SUBMITTER: Gupta A 

PROVIDER: S-EPMC8992496 | biostudies-literature | 2020 3rd Quarter

REPOSITORIES: biostudies-literature