Ontology highlight
ABSTRACT:
SUBMITTER: Rytlewski J
PROVIDER: S-EPMC8992584 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Rytlewski Jeff J Brockman Qierra R QR Dodd Rebecca D RD Milhem Mohammed M Monga Varun V
Cancer drug resistance (Alhambra, Calif.) 20220104 1
Sarcomas are a class of rare malignancies of mesenchymal origin with a heterogeneous histological spectrum. They are classically associated with poor outcomes, especially once metastasized. A path to improving clinical outcomes may be made through modifying the epigenome, where a variety of sarcomas demonstrate changes that contribute to their oncogenic phenotypes. This Perspective article identifies and describes changes in the sarcoma genome, while discussing specific epigenetic changes and th ...[more]