Novel insights into the mechanism of cell cycle kinases Mec1(ATR) and Tel1(ATM).

ABSTRACT: DNA replication is a highly precise process which usually functions in a perfect rhythm with cell cycle progression. However, cells are constantly faced with various kinds of obstacles such as blocks in DNA replication, lack of availability of precursors and improper chromosome alignment. When these problems are not addressed, they may lead to chromosome instability and the accumulation of mutations, and even cell death. Therefore, the cell has developed response mechanisms to keep most of these situations under control. Of the many factors that participate in this DNA damage response, members of the family of phosphatidylinositol 3-kinase-related protein kinases (PIKKs) orchestrate the response landscape. Our understanding of two members of the PIKK family, human ATR (yeast Mec1) and ATM

SUBMITTER: Tannous EA 

PROVIDER: S-EPMC8992879 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature