Positive associations between cannabis and alcohol use polygenic risk scores and phenotypic opioid misuse among African-Americans.

ABSTRACT:

Background

This study examined whether polygenic risk scores (PRS) for lifetime cannabis and alcohol use were associated with misusing opioids, and whether sex differences existed in these relations in an urban, African-American sample.

Methods

Data were drawn from three cohorts of participants (N = 1,103; 45% male) who were recruited in first grade as part of a series of elementary school-based, universal preventive intervention trials conducted in a Mid-Atlantic region of the U.S. In young adulthood, participants provided a DNA sample and reported on whether they had used heroin or misused prescription opioids in their lifetime. Three substance use PRS were computed based on prior GWAS: lifetime cannabis use from Pasman et al. (2018), heavy drinking indexed via maximum num

SUBMITTER: Rabinowitz JA 

PROVIDER: S-EPMC8993003 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature