Vimentin Suppresses Inflammation and Tumorigenesis in the Mouse Intestine.

ABSTRACT: Vimentin has been implicated in wound healing, inflammation, and cancer, but its functional contribution to intestinal diseases is poorly understood. To study how vimentin is involved during tissue injury and repair of simple epithelium, we induced colonic epithelial cell damage in the vimentin null (Vim^-/-) mouse model. Vim^-/- mice challenged with dextran sodium sulfate (DSS) had worse colitis manifestations than wild-type (WT) mice. Vim^-/- colons also produced more reactive oxygen and nitrogen species, possibly contributing to the pathogenesis of gut inflammation and tumorigenesis than in WT mice. We subsequently describe that CD11b⁺ macrophages served as the mainly cellular source of reactive oxygen species (ROS) production via vimentin

SUBMITTER: Wang L 

PROVIDER: S-EPMC8993042 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature