Key changes in chromatin mark mammalian epidermal differentiation and ageing.

ABSTRACT: Dynamic shifts in chromatin states occur during embryonic epidermal development to support diverse epigenetic pathways that regulate skin formation and differentiation. However, it is not known whether the epigenomes established during embryonic development are maintained into adulthood or how these epigenetic mechanisms may be altered upon physiological ageing of the tissue. Here, we systematically profiled the nuclear enrichment of five key histone modifications in young and aged mouse epidermis and identified distinct chromatin states that are tightly correlated with cellular differentiation, as well as chromatin alterations that accompanied epidermal ageing. Our data showed that histone modifications, which become differentially enriched in undifferentiated basal or differentiated supr

SUBMITTER: Dube CT 

PROVIDER: S-EPMC8993096 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature