Pathogenicity of SARS-CoV-2 Omicron (R346K) variant in Syrian hamsters and its cross-neutralization with different variants of concern.

ABSTRACT:

Background

SARS-CoV-2 Omicron variant is rampantly spreading across the globe. We assessed the pathogenicity and immune response generated by BA.1.1 sub-lineage of SARS-CoV-2 [Omicron (R346K) variant] in 5 to 6-week old Syrian hamsters and compared the observations with that of Delta variant infection.

Methods

Virus shedding, organ viral load, lung disease and immune response generated in hamsters were sequentially assessed.

Findings

The disease characteristics of the Omicron (R346K) variant were found to be similar to that of the Delta variant infection in hamsters like viral replication in the respiratory tract and interstitial pneumonia. The Omicron (R346K) infected hamsters demonstrated lesser body weight reduction and viral RNA load in the throat swab and nasal w

SUBMITTER: Mohandas S 

PROVIDER: S-EPMC8993158 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature