A Chemomechanical Model for Regulation of Contractility in the Embryonic Brain Tube.

ABSTRACT: Morphogenesis is regulated by genetic, biochemical, and biomechanical factors, but the feedback controlling the interactions between these factors remains poorly understood. A previous study has found that compressing the brain tube of the early chick embryo induces changes in contractility and nuclear shape in the neuroepithelial wall. Assuming this response involves mechanical feedback, we use experiments and computational modeling to investigate a hypothetical mechanism behind the observed behavior. First, we measured nuclear circularity in embryonic chick brains subjected to transverse compression. Immediately after loading, the circularity varied regionally and appeared to reflect the local state of stress in the wall. After three hours of culture with sustained compression, however,

SUBMITTER: Oltean A 

PROVIDER: S-EPMC8993162 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature