Novel protein markers of androgen activity in humans: proteomic study of plasma from young chemically castrated men.

ABSTRACT:

Background

Reliable biomarkers of androgen activity in humans are lacking. The aim of this study was, therefore, to identify new protein markers of biological androgen activity and test their predictive value in relation to low vs normal testosterone values and some androgen deficiency linked pathologies.

Methods

Blood samples from 30 healthy GnRH antagonist treated males were collected at three time points: (1) before GnRH antagonist administration; (2) 3 weeks later, just before testosterone undecanoate injection, and (3) after additional 2 weeks. Subsequently, they were analyzed by mass spectrometry to identify potential protein biomarkers of testosterone activity. Levels of proteins most significantly associated with testosterone fluctuations were further tested in a coh

SUBMITTER: Giwercman A 

PROVIDER: S-EPMC8993215 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature