Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling.

ABSTRACT: Production and emigration of neural crest cells is a transient process followed by the emergence of the definitive roof plate. The mechanisms regulating the end of neural crest ontogeny are poorly understood. Whereas early crest development is stimulated by mesoderm-derived retinoic acid, we report that the end of the neural crest period is regulated by retinoic acid synthesized in the dorsal neural tube. Inhibition of retinoic acid signaling in the neural tube prevents the normal upregulation of BMP inhibitors in the nascent roof plate and prolongs the period of BMP responsiveness which otherwise ceases close to roof plate establishment. Consequently, neural crest production and emigration are extended well into the roof plate stage. In turn, extending the activity of neural crest-specifi

SUBMITTER: Rekler D 

PROVIDER: S-EPMC8993216 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature