Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement.

ABSTRACT: Recent studies indicate that the human intestinal microbiota could impact the outcome of infection by Vibrio cholerae, the etiological agent of the diarrheal disease cholera. A commensal bacterium, Paracoccus aminovorans, was previously identified in high abundance in stool collected from individuals infected with V. cholerae when compared to stool from uninfected persons. However, if and how P. aminovorans interacts with V. cholerae has not been experimentally determined; moreover, whether any association between this bacterium alters the behaviors of V. cholerae to affect the disease outcome is unclear. Here, we show that P. aminovorans and V. cholerae together form dual-species biofilm structure at the air-liquid interface, with pr

SUBMITTER: Barrasso K 

PROVIDER: S-EPMC8993218 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature