A multi-omics-based investigation of the immunological and prognostic impact of necroptosis-related genes in patients with hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the most common histological subtype of liver cancer and the third leading cause of death from cancer globally. Recent studies suggested cell death is also a key regulator of tumour progression. The purpose of this study was to generate a new predictive signature for HCC patients based on a complete analysis of necroptosis-associated genes.

Methods

We extracted the mRNA expression profiles of HCC patients from the TCGA and ICGC databases and their clinical data. In addition, we used the IMvigor210 cohort to validate our model molecule's ability to predict the effect of immunotherapy. In the TCGA cohort, a seven-gene risk-prognostic model was constructed using univariate cox-Lasoo regression. External validation was conducted using

SUBMITTER: Yang H 

PROVIDER: S-EPMC8993599 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature