Pyroptosis patterns and immune infiltrates characterization in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Pyroptosis plays an essential role in tumor immune responses and inflammation related to chemotherapy. Herein, we studied the characteristic patterns of pyroptosis in head and neck squamous cell carcinoma (HNSCC) to determine their prognostic and therapeutic effects.

Methods

Consensus clustering analysis was performed to classify patients into pyroptosis or gene clusters. A novel pyroptosis score was constructed by principal component analysis. Kaplan-Meier survival curves were used to show the prognostic value. We also assessed the functional enrichment, tumor mutation burden, immune cell infiltration, and the sensitivity to chemotherapy and immunotherapy between high and low pyroptosis score group.

Results

Two distinct pyroptosis clusters were defined bas

SUBMITTER: Deng H 

PROVIDER: S-EPMC8993614 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature