Methylation- and homologous recombination deficiency-related mutant genes predict the prognosis of lung adenocarcinoma.

ABSTRACT:

Background

Lung adenocarcinoma (LUAD) is a lung cancer subtype with poor prognosis. We investigated the prognostic value of methylation- and homologous recombination deficiency (HRD)-associated gene signatures in LUAD.

Methods

Data on RNA sequencing, somatic mutations, and methylation were obtained from TCGA database. HRD scores were used to stratify patients with LUAD into high and low HRD groups and identify differentially mutated and expressed genes (DMEGs). Pearson correlation analysis between DMEGs and methylation yielded methylation-associated DMEGs. Cox regression analysis was used to construct a prognostic model, and the distribution of clinical features in the high- and low-risk groups was compared.

Results

Patients with different HRD scores showed different

SUBMITTER: Nie GJ 

PROVIDER: S-EPMC8993616 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature