Alterations of gut microbiota-derived metabolites in gestational diabetes mellitus and clinical significance.

ABSTRACT:

Background

The change in the characteristics of the gut microbiota is linked to gestational diabetes mellitus (GDM). However, whether and how the gut microbiota-derived metabolites change in GDM is uncertain. Here, we aimed to determine associations between the gut microbiota-derived metabolites and GDM.

Methods

Using targeted metabolomics approaches, 7 types of short-chain fatty acids (SCFAs), 38 types of bile acids (BAs), and 5 types of trimethylamine N-oxide (TMAO), and its derivatives of serum samples were obtained from pregnant women with GDM (n = 24), and healthy pregnant controls (HC, n = 28) were detected to identify the metabolic signature of GDM to investigate the potential biomarkers. Moreover, we assessed the associations between gut microbiota-derived metabolite

SUBMITTER: Gao Y 

PROVIDER: S-EPMC8993618 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature