Signal transducer and activator of transcription family is a prognostic marker associated with immune infiltration in endometrial cancer.

ABSTRACT:

Background

Signal transducer and activator of transcription (STAT) is a unique protein family that binds to DNA and plays a vital role in regulating major physiological cellular processes. Seven STAT genes have been identified in the human genome. Several studies suggest STAT family members to be involved in cancer development, progression, and metastasis. However, the predictive relationship between STAT family expression and immune cell infiltration in endometrial cancer remains unknown.

Methods

We explored STAT family expression and prognosis in endometrial cancer using various databases. The STRING, GeneMANIA, and DAVID databases, along with GO and KEGG analyses, were used to construct a protein interaction network of related genes. Finally, the TIMER database and ssGSEA

SUBMITTER: Zhou XY 

PROVIDER: S-EPMC8993664 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature