Dataset Information

Accuracy of PET quantification in [⁶⁸Ga]Ga-pentixafor PET/MR imaging of carotid plaques.

ABSTRACT:

Aim

The aim of this study was to evaluate and correct for partial-volume-effects (PVE) on [⁶⁸Ga]Ga-Pentixafor uptake in atherosclerotic plaques of the carotid arteries, and the impact of ignoring bone in MR-based attenuation correction (MR-AC).

Methods

Twenty [⁶⁸Ga]Ga-pentixafor PET/MR examinations including a high-resolution T2-TSE MR of the neck were included in this study. Carotid plaques located at the carotid bifurcation were delineated and the anatomical information was used for partial-volume-correction (PVC). Mean and max tissue-to-background ratios (TBR) of the [⁶⁸Ga]Ga-Pentixafor uptake were compared for standard and PVC-PET images. A potential influence of ignoring bone in MR-AC was assessed in a subset of the data reconstructed after incorporating bone into MR-AC and a subsequent comparison of standardized-uptake values (SUV).

Results

In total, 34 atherosclerotic plaques were identified. Following PVC, mean and max TBR increased by 77 and 95%, respectively, when averaged across lesions. When accounting for bone in the MR-AC, SUV of plaque changed by 0.5%.

Conclusion

Quantitative readings of [⁶⁸Ga]Ga-pentixafor uptake in plaques are strongly affected by PVE, which can be reduced by PVC. Including bone information into the MR-AC yielded no clinically relevant effect on tracer quantification.

SUBMITTER: Rausch I

PROVIDER: S-EPMC8993720 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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Publications

Accuracy of PET quantification in [<sup>68</sup>Ga]Ga-pentixafor PET/MR imaging of carotid plaques.

Rausch Ivo I Beitzke Dietrich D Li Xiang X Pfaff Sahra S Rasul Sazan S Haug Alexander R AR Mayerhoefer Marius E ME Hacker Marcus M Beyer Thomas T Cal-González Jacobo J

Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20200721 2

<h4>Aim</h4>The aim of this study was to evaluate and correct for partial-volume-effects (PVE) on [<sup>68</sup>Ga]Ga-Pentixafor uptake in atherosclerotic plaques of the carotid arteries, and the impact of ignoring bone in MR-based attenuation correction (MR-AC).<h4>Methods</h4>Twenty [<sup>68</sup>Ga]Ga-pentixafor PET/MR examinations including a high-resolution T2-TSE MR of the neck were included in this study. Carotid plaques located at the carotid bifurcation were delineated and the anatomica ...[more]

PMID: 32696137

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Dataset Information

Accuracy of PET quantification in [⁶⁸Ga]Ga-pentixafor PET/MR imaging of carotid plaques.

Aim

Methods

Results

Conclusion

Publications

Accuracy of PET quantification in [<sup>68</sup>Ga]Ga-pentixafor PET/MR imaging of carotid plaques.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Accuracy of PET quantification in [68Ga]Ga-pentixafor PET/MR imaging of carotid plaques.

Aim

Methods

Results

Conclusion

Publications

Accuracy of PET quantification in [<sup>68</sup>Ga]Ga-pentixafor PET/MR imaging of carotid plaques.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Accuracy of PET quantification in [⁶⁸Ga]Ga-pentixafor PET/MR imaging of carotid plaques.