Accuracy of PET quantification in [⁶⁸Ga]Ga-pentixafor PET/MR imaging of carotid plaques.

ABSTRACT:

Aim

The aim of this study was to evaluate and correct for partial-volume-effects (PVE) on [⁶⁸Ga]Ga-Pentixafor uptake in atherosclerotic plaques of the carotid arteries, and the impact of ignoring bone in MR-based attenuation correction (MR-AC).

Methods

Twenty [⁶⁸Ga]Ga-pentixafor PET/MR examinations including a high-resolution T2-TSE MR of the neck were included in this study. Carotid plaques located at the carotid bifurcation were delineated and the anatomical information was used for partial-volume-correction (PVC). Mean and max tissue-to-background ratios (TBR) of the [⁶⁸Ga]Ga-Pentixafor uptake were compared for standard and PVC-PET images. A potential influence of ignoring bone in MR-AC was assessed in a subset of the data reconstructed af

SUBMITTER: Rausch I 

PROVIDER: S-EPMC8993720 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature