Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers.

ABSTRACT: The Hippo signal transduction network regulates transcription through Yap/Taz-Tead1-4 in many tissues including skeletal muscle. Whilst transgenic mice have been generated for many Hippo genes, the resultant skeletal muscle phenotypes were not always characterized. Here, we aimed to phenotype the hindlimb muscles of Hippo gene-mutated Lats1^-/-, Mst2^-/-, Vgll3^-/-, and Vgll4^+/- mice. This analysis revealed that Lats1^-/- mice have 11% more slow type I fibers than age and sex-matched wild-type controls. Moreover, the mRNA expression of slow Myh7 increased by 50%, and the concentration of type I myosin heavy chain is 80% higher in Lats1^-/- mice than in age and sex-matched wild-type controls. Second, to find out whether exercise-r

SUBMITTER: Nezhad FY 

PROVIDER: S-EPMC8993742 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature