PET-CT imaging of pulmonary inflammation using [⁶⁸Ga]Ga-DOTA-TATE.

ABSTRACT:

Purpose

In the characterization of severe lung diseases, early detection of specific inflammatory cells could help to monitor patients' response to therapy and increase chances of survival. Macrophages contribute to regulating the resolution and termination of inflammation and have increasingly been of interest for targeted therapies. [⁶⁸Ga]Ga-DOTA-TATE is an established clinical radiopharmaceutical targeting somatostatin receptor subtype 2 (SSTR 2). Since activated macrophages (M1) overexpress SSTR 2, the aim of this study was to investigate the applicability of [⁶⁸Ga]Ga-DOTA-TATE for positron emission tomography (PET) imaging of M1 macrophages in pulmonary inflammation.

Methods

Inflammation in the pig lungs was induced by warm saline lavage followed b

SUBMITTER: Puuvuori E 

PROVIDER: S-EPMC8994000 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature