Rapid comparative evaluation of SARS-CoV-2 rapid point-of-care antigen tests.

ABSTRACT:

Purpose

The objective of this study was to develop a scalable approach for direct comparison of the analytical sensitivities of commercially available SARS-CoV-2 antigen point-of-care tests (AgPOCTs) to rapidly identify poor-performing products.

Methods

We present a methodology for quick assessment of the sensitivity of SARS-CoV-2 AgPOCTs suitable for quality evaluation of many different products. We established reference samples with high, medium, and low SARS-CoV-2 viral loads along with a SARS-CoV-2 negative control sample. Test samples were used to semi-quantitatively assess the analytical sensitivities of 32 different commercial AgPOCTs in a head-to-head comparison.

Results

Among 32 SARS-CoV-2 AgPOCTs tested, we observe sensitivity differences across a broad rang

SUBMITTER: Denzler A 

PROVIDER: S-EPMC8994089 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature