Function of the Retinal Pigment Epithelium in Patients With Neurofibromatosis Type 1.

ABSTRACT:

Purpose

Retinal and choroidal abnormalities in neurofibromatosis type 1 (NF1) remain poorly studied. It has been reported, however, that the function of the retinal pigment epithelium (RPE) in NF1 was abnormal, with a supra-normal Arden ratio of the electro-oculogram (EOG). This study aims to evaluate the function of the RPE, using EOG, first in patients with NF1 compared to controls and second in patients with NF1 with choroidal abnormalities compared to patients with NF1 without choroidal abnormalities.

Methods

This prospective case-control study included 20 patients with NF1 (10 patients with choroidal abnormalities and 10 patients without) and 10 healthy patients, matched for age. A complete ophthalmologic assessment with multimodal imaging, an EOG, and a full-field elec

SUBMITTER: Touze R 

PROVIDER: S-EPMC8994170 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature