The response to prolonged fasting in hypothalamic serotonin transporter availability is blunted in obesity.

ABSTRACT:

Background and aims

Serotonergic and dopaminergic systems in the brain are essential for homeostatic and reward-associated regulation of food intake and systemic energy metabolism. It is largely unknown how fasting influences these systems or if such effects are altered in humans with obesity. We therefore aimed to evaluate the effects of fasting on hypothalamic/thalamic serotonin transporter (SERT) and striatal dopamine transporter (DAT) availability in lean subjects and subjects with obesity.

Methods

In this randomized controlled cross-over trial, we assessed the effects of 12 vs 24 h of fasting on SERT and DAT availability in the hypothalamus/thalamus and striatum, respectively, using SPECT imaging in 10 lean men and 10 men with obesity.

Results

As compared with th

SUBMITTER: van Galen KA 

PROVIDER: S-EPMC8994212 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature