Fetal growth restriction: associated genetic etiology and pregnancy outcomes in a tertiary referral center.

ABSTRACT:

Background

The etiology of fetal growth restriction (FGR) is complex and currently, there is a paucity of research about the genetic etiology of fetal growth restriction. We investigated the genetic associations and pregnancy outcomes in cases of fetal growth restriction.

Methods

A retrospective analysis of 210 pregnant women with fetal growth restriction was performed using karyotype analysis and single nucleotide polymorphism arrays (SNP-array). The differences in pathogenic copy number variation (CNV) detected by the two methods were compared. At the same time, the fetuses were divided into three groups: isolated FGR (n = 117), FGR with ultrasonographic soft markers (n = 48), and FGR with ultrasonographic structural anomalies (n = 45). Further, the differences in pathogen

SUBMITTER: Cai M 

PROVIDER: S-EPMC8994287 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature