Immune evader cancer stem cells direct the perspective approaches to cancer immunotherapy.

ABSTRACT: Exploration of tumor immunity leads to the development of immune checkpoint inhibitors and cell-based immunotherapies which improve the clinical outcomes in several tumor types. However, the poor clinical efficacy of these treatments observed for other tumors could be attributed to the inherent complex tumor microenvironment (TME), cellular heterogeneity, and stemness driven by cancer stem cells (CSCs). CSC-specific characteristics provide the bulk tumor surveillance and resistance to entire eradication upon conventional therapies. CSCs-immune cells crosstalk creates an immunosuppressive TME that reshapes the stemness in tumor cells, resulting in tumor formation and progression. Thus, identifying the immunological features of CSCs could introduce the therapeutic targets with powerful antit

SUBMITTER: Dianat-Moghadam H 

PROVIDER: S-EPMC8994338 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature