Integrative proteomic characterization of trace FFPE samples in early-stage gastrointestinal cancer.

ABSTRACT:

Background

The surveillance and therapy of early-stage cancer would be better for patients' prognosis. However, the extreme trace amount of tissue samples in different stages have limited in portraying the characterization of early-stage cancer. Therefore, we focused on and presented comprehensive proteomic and phosphoproproteomic profiling of the trace FFPE samples from early-stage gastrointestinal cancer, and then explored the potential biomarkers of early-stage gastrointestinal cancer.

Methods

In this study, a quantitative proteomic method with chromatography with mass spectrometry (LC-MS/MS) was used to analyse the proteomic difference between the trace early-stage esophageal squamous cell carcinoma (EESCC) and early-stage duodenum adenocarcinoma cancer (EDAC).

Result

SUBMITTER: Li L 

PROVIDER: S-EPMC8994365 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature