Individual human cortical progenitors can produce excitatory and inhibitory neurons.

ABSTRACT: The cerebral cortex is a cellularly complex structure comprising a rich diversity of neuronal and glial cell types. Cortical neurons can be broadly categorized into two classes-excitatory neurons that use the neurotransmitter glutamate, and inhibitory interneurons that use γ-aminobutyric acid (GABA). Previous developmental studies in rodents have led to a prevailing model in which excitatory neurons are born from progenitors located in the cortex, whereas cortical interneurons are born from a separate population of progenitors located outside the developing cortex in the ganglionic eminences^1-5. However, the developmental potential of human cortical progenitors has not been thoroughly explored. Here we show that, in addition to excitatory neurons and glia, human cortical progeni

SUBMITTER: Delgado RN 

PROVIDER: S-EPMC8994470 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature