Colon transcriptome is modified by a dietary pattern/atorvastatin interaction in the Ossabaw pig.

ABSTRACT: Optimizing diet quality in conjunction with statin therapy is currently the most common approach for coronary artery disease (CAD) risk management. Although effects on the cardiovascular system have been extensively investigated, little is known about the effect of these interventions in the colon and subsequent associations with CAD progression. To address this gap, Ossabaw pigs were randomly allocated to receive, for a six-month period, isocaloric amounts of either a heart healthy-type diet (HHD; high in unrefined carbohydrate, unsaturated fat, fiber, supplemented with fish oil, and low in cholesterol) or a Western-type diet (WD; high in refined carbohydrate, saturated fat and cholesterol, and low in fiber), without or with atorvastatin therapy. At the end of the intervention period, col

SUBMITTER: Ye S 

PROVIDER: S-EPMC8994518 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature