Migraine Prevention with Erenumab: Focus on Patient Selection, Perspectives and Outcomes.

ABSTRACT: Erenumab is a monoclonal antibody targeting the calcitonin gene-related peptide (CGRP) receptor suitable for episodic and chronic migraine prevention. Randomized clinical trials proved the superiority of erenumab to placebo in a strictly selected population, while real-world studies confirmed treatment efficacy in more severe forms of disease - most patients suffered from chronic migraine with medication overuse headache, had prior treatment failures, and long disease duration. According to guidelines, anti-CGRP pathway monoclonal antibodies should be reserved to patients who failed or have contraindication to several classes of preventive treatments. However, their ease of use, tolerability and efficacy make these monoclonal antibodies ideally suitable for most patients with migraine; cos

SUBMITTER: De Matteis E 

PROVIDER: S-EPMC8994624 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature