Acute gene expression changes in the mouse hippocampus following a combined Gulf War toxicant exposure.

ABSTRACT:

Aims

Approximately 30% of the nearly 700,000 Veterans who were deployed to the Gulf War from 1990 to 1991 have reported experiencing a variety of symptoms including difficulties with learning and memory, depression and anxiety, and increased incidence of neurodegenerative diseases. Combined toxicant exposure to acetylcholinesterase (AChE) inhibitors has been studied extensively as a likely risk factor. In this study, we modeled Gulf War exposure in male C57Bl/6J mice with simultaneous administration of three chemicals implicated as exposure hazards for Gulf War Veterans: pyridostigmine bromide, the anti-sarin prophylactic; chlorpyrifos, an organophosphate insecticide; and the repellant N,N-diethyl-m-toluamide (DEET).

Main methods

Following two weeks of daily exposure, we exa

SUBMITTER: Murray KE 

PROVIDER: S-EPMC8994630 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature