Chemical and Biomolecular Strategies for STING Pathway Activation in Cancer Immunotherapy.

ABSTRACT: The stimulator of interferon genes (STING) cellular signaling pathway is a promising target for cancer immunotherapy. Activation of the intracellular STING protein triggers the production of a multifaceted array of immunostimulatory molecules, which, in the proper context, can drive dendritic cell maturation, antitumor macrophage polarization, T cell priming and activation, natural killer cell activation, vascular reprogramming, and/or cancer cell death, resulting in immune-mediated tumor elimination and generation of antitumor immune memory. Accordingly, there is a significant amount of ongoing preclinical and clinical research toward further understanding the role of the STING pathway in cancer immune surveillance as well as the development of modulators of the pathway as a strategy to s

SUBMITTER: Garland KM 

PROVIDER: S-EPMC8994686 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature